慢性肺原性心脏病对左心室功能的影响

Functional Changes of Left Ventricle in Chronic Cor Pulmonale

目的研究慢性肺原性心脏病（肺心病）右心功能损害对左心室功能的影响。方法分析２１例慢性肺心病的超声心动图，以二尖瓣Ａ／Ｅ比值为指标观察左心室舒张功能；测量ＥＦ、ＣＯ、ＳＶ、ＣＩ、ＦＳ作为观察左心室收缩功能的指标；并测量左室心腔内径及计算左室心肌重量指数。结果研究发现肺心病组二尖瓣Ａ／Ｅ比值为１．１４±０．１４，与对照组比较Ｐ＜０．０１。ＥＦ、ＣＯ、ＳＶ、ＣＩ、ＦＳ分别为６１．９０±１１．８２，４．４７±０．８９，５６．７１±１３．７０，６３．２０±０．５８，与对照组比较Ｐ＞０．０５。心肌重量指数８３．７６±１９．１０，与对照组无统计学差异。结论慢性肺心病（１）左室舒张早期充盈受损；（２）本研究未发现左室收缩功能减退；（３）不伴有左心腔扩大或左室心肌肥厚。

Objective\ To study the influence of left ventricle in right ventricular dysfunction.\ Methods\ In a retrospective review of echocardiogram of 21 patients with chronic cor pulmonale and 15 healthy controls,A/E of bicuspid valve,left ventricular systolic function and LVMI were analysed.\ Results\ A/E of bicuspid valve in cor pulmonale was 1 14±0 14 and greater than that in healthy controls (P<0 01). \ There were no significant difference of EF,CO,SV,CI,FS between two groups(P>0 05). \ LVMI were 83 76±19 10(cor pulmonale) and 80 77±18 33(healthy controls)(P>0 05).\ Conclusion\ There was a damage of early diastolic function of left ventricle in cor pulmonale.\ No left ventricular systolic dysfunction and left ventricular hypertrophy were found.