原发性小肠癌癌胚抗原表达及其粘液成分的变化

Carcinoembryonic Antigen Expression and Mucus Ingredient Change in Primary Small Intestine Carcinoma

目的研究原发性小肠癌癌胚抗原（ＣＥＡ）表达和粘液性质变化特点及其临床意义。方法采用免疫组化和粘液组化的方法，对小肠癌及其癌旁组织中ＣＥＡ的分布及粘液成分的变化进行观察。结果小肠粘膜从正常到不典型增生再发展到癌变的过程中，其ＣＥＡ的分泌及硫酸粘液、非硫酸粘液的分泌比例有显著改变（Ｐ＜０．０１）。结论检测ＣＥＡ和粘液成分的改变对判断原发性小肠癌的生物行为和癌前病变有参考价值。

Objective\ To study carcinoembryonic antigen(CEA) expression and mucus ingredient change of primary small intestine carcinoma and their clinical significance.\ Methods\ Using immunohistochemistry and mucinhistochemistry to observe the secretion of CEA and variation of mucus ingredient.\ Results\ In the transition of the small intestine mucus membrane from atypical hyperplasia to carcinoma,both CEA secretion and the proportion of sulfuric to non sulfuric acid mucin secretion have marked changes(P<0 01).\ Conclusion\ Detection of CEA and mucin changes is valuable for the judgement of biological behavior and precancerous dysplasia in small intestine carcinoma.