812株非结核分枝杆菌临床分离株流行病学特征分析

Analysis on the epidemiological characteristics of 812 non-tuberculous mycobacteria strains

目的探讨非结核分枝杆菌的流行病学特征,为非结核分枝杆菌病防治策略的确立提供依据。方法对广州市结核病肺部肿瘤防治所2004—2009年分枝杆菌培养的实验室资料进行统计分析。结果 （1）6年间,共进行分枝杆菌培养32 906例,6 083例培养阳性。其中：对4 207例进行了结核分枝杆菌复合群与非结核分枝杆菌分群,812株为非结核分枝杆菌,占19.3%。（2）对558株非结核分枝杆菌进行了菌种或复合群鉴定,种群分布达22种,菌种分布前5的顺位为：龟-脓肿分枝杆菌复合群、鸟-胞内分枝杆菌复合群、偶然分枝菌、戈登分枝杆菌和耻垢分枝杆菌。（3）荷菌者男女比例约为3∶2,多为15~74岁患者,其中15~54岁患者占67.3%。结论与广州市前10年相比,非结核分枝杆菌临床分离率有上升趋势,感染人群年龄前移,且以致病性菌种居多,值得重视。

Objective To explore the epidemiological characteristics of non-tuberculous mycobacterium（NTM） and to provide the basis for the control strategies of NTM diseases.Methods Relevant laboratory data from 2004 to 2009 regarding mycobacterial culture and species identification in Guangzhou Tuberculosis and Pulmonary Tumor Control Institute were analyzed retrospectively.Results Firstly,6083 of 32906 cases were culture positive during 6 years period,in which 4207 strains were identified,and 812 strains（19.31%） were identified as NTM.Secondly,558 NTM strains were performed species identification,in which 22 species or complex were identified.The top five species or complex with the highest occurrence frequency were M.chclonae-abscessus complex,M.avium-intracellulare complex,M.fortuitum,M.gordonae and M.smegmatis.Finally,the ratio of male and female was about 3 to 2.The age range of the NTM carriers was 15～74 years old,and 67.30% of them were at 15～54 years age.Conclusion Compared the current NTM epidemic situation in this region with that in the during previous 10 years,the rising tendency of NTM isolation rate is very clear,and the age of the persons carrying NTM is younger.All these phenomena should be paid attention.