氟哌噻吨美利曲辛片治疗伴焦虑抑郁障碍的功能性胃肠病的临床观察

Effects of flupentixol and melitracen tablets in the treatment of functional gastrointestinal disorders combined with anxiety or depression

目的:观察氟哌噻吨美利曲辛片(商品名:黛力新)对有焦虑抑郁障碍的功能性胃肠病患者的临床疗效。方法:将87例有焦虑抑郁障碍的功能性胃肠病患者随机分为两组,治疗组41例及对照组46例,均予抑酸、促动力等基础治疗,治疗组另加服黛力新,随访8周,分别在治疗前,治疗后2,4,6,8周时对患者进行消化道症状积分、疗效分级、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评分。结果:治疗后治疗组的消化道症状积分、HAMD和HAMA评分明显低于对照组;疗效分级明显优于对照组(P<0.05)。两组患者治疗后的消化道症状积分、HAMD和HAMA评分均较治疗前下降,且治疗组下降更明显(P<0.05)。结论:氟哌噻吨美利曲片治疗有焦虑抑郁障碍的功能性胃肠病患者,对改善消化道症状及情绪障碍有显著疗效。

OBECTIVE To observe the clinical effects of flupentixol and melitracen tablets（Deanxit） in the treatment of the cases of functional gastrointestinal disorders combined with anxiety or depressiorL METHODS Eighty-seven patienls of functional gastrointestinal disorders combined with anxiety or depression were divided into two groups： 1. Treat group（n = 41） received routine medicine and Deanxit;2. Control group（n = 46） received routine medicine. They were all observed for 8 weeks. 0, 2,4,6,8 weeks after treatment, every patient was made scores of 9 gastrointestinal symptoms and a level of therapeutic effica cy, and assessed by HAMD, HAMA. RESULTS In both groups the scores of 9 symptoms , HAMD and HAMA were all lower after treatment,and the treatment group was superior（P〈0. 05）. Otherwise, the therapeutic efficacy of treatment group was superior to that of control group（P〈0.05）. CONCLUSION It showed that Deanxit can improve symptom largely in the pa- tients of functional gastrointestinal disorders combined with anxiety or depression, including psychic and somatic symptoms.