原发性高血压合并代谢综合征患者游离脂肪酸对颈动脉内-中膜厚度的影响

Effect of free fatty acids on carotid intima-media thickness in patients with hypertension and metabolic syndrome

目的探讨原发性高血压(高血压)合并代谢综合征(metabolism syndrome,MS)患者的血清游离脂肪酸(free fatty acids,FFA)浓度对颈动脉内-中膜厚度(intima-media thickness,IMT)的影响。方法选择高血压合并MS患者69例(MS组);单纯高血压57例(非MS组),另外选取健康体检者50名作为对照组。检测所有患者的血清FFA、体质量指数、颈动脉IMT及IMT增厚发生率情况。结果 MS组的体质量指数、三酰甘油、空腹血糖浓度均高于非MS组和对照组,差异有统计学意义(P<0.05)。MS组血清FFA浓度高于非MS组及对照组,差异有统计学意义[(562.11±55.12)μmol/L vs.(402.65±49.53)μmol/L,P<0.01;(562.11±55.12)μmol/L vs.(356.23±45.93)μmol/L,P<0.01]。MS组颈动脉IMT高于非MS组及对照组,差异有统计学意义[(1.10±0.13)mm vs.(0.82±0.12)mm,P<0.01;(1.10±0.13)mm vs.(0.70±0.11)mm,P<0.01]。MS组颈动脉IMT增厚发生率显著高于非MS组及对照组,差异有统计学意义(29.3%vs.21.8%,P<0.01;29.3%vs.5.0%,P<0.01)。结论高血压伴MS患者的血清FFA浓度升高使颈动脉IMT增厚,促进MS患者动脉粥样硬化的形成。

Objectives To investigate the effect of serum free fatty acids（FFA） on carotid intima-media thickness（IMT） in patients with hypertension and metabolic syndrome（MS）.Methods Carotid IMT,concentration of serum FFA,incidence of IMT thickening and body mass index were detected in 69 hypertensive patients with MS（MS group）,57 hypertensive patients without MS（Non-MS group）,and 50 healthy controls（NC group）.Results The body mass index,serum concentrations of triglyceride,fasting blood glucose in MS group were significantly higher than those in Non-MS group and NC group（P0.05）.Concentration of serum FFA in MS group was significantly higher than Non-MS group and NC group [（562.11±55.12）μmol/L vs.（402.65±49.53）μmol/L,P0.01;（562.11±55.12）μmol/L vs.（356.23±45.93）μmol/L,P0.01].Carotid IMT in MS group was significantly thicker than those in Non-MS group and NC group [（1.10±0.13）mm vs.（0.82±0.12）mm,P0.01;（1.10±0.13）mm vs.（0.70±0.11）mm,P0.01].In addition,incidence of IMT thickening in MS group was significantly higher than those in Non-MS group and NC group（29.3% vs.21.8%,P0.01;29.3% vs.5.0%,P0.01）.Conclusions Concentration of serum FFA causes carotid IMT to become thinker in patients with hypertension and MS.