大鼠腹腔注射甲基苯丙胺的条件性位置偏爱效应及其受体机制

Conditioned place preference of methamphetamine in rats and its receptor mechanism

目的：评价甲基苯丙胺的位置偏爱效应并探讨其受体作用。方法：采用条件性位置偏爱方法，训练程序为倾向性程序。结果：腹腔注射甲基苯丙胺（ｍｅｔｈａｍｐｈｅｔａｍｉｎｅ，ＭＡ）０．５、１、２、８ｍｇ·ｋｇ－１，大鼠在对伴药盒产生了位置偏爱效应，而且在一定剂量范围内随着剂量的增加，其偏爱程度有所增强。皮下注射Ｄ１受体拮抗剂ＳＣＨ２３３９０（０．０４，０．０８，０．１６ｍｇ·ｋｇ－１），均可拮抗ＭＡ（２ｍｇ·ｋｇ－１）的偏爱效应。皮下注射Ｄ２受体拮抗剂舒必利（４０和８０ｍｇ·ｋｇ－１）也可拮抗ＭＡ（２ｍｇｋｇ－１ｉ．ｐ．）的偏爱效应。结论：ＭＡ可产生条件性位置偏爱效应，Ｄ１和Ｄ２受体在调节ＭＡ偏爱效应中均发挥作用。

Objective: To assess the conditioned place preference (CPP) effect of methamphetamine (MA) and its neuro mechanism in rats. Methods: The CPP paradigm was utilized. Results: The rats treated with MA (0.5,1,2 and 8 mg·kg -1 , i.p..) produced the place preference in dose dependent manner. SCH23390 (0.04,0.08,0.16 mg·kg -1 , sc), a kind of D 1 receptor antagonist, blocked the CPP effect of MA (2 mg·kg -1 , i.p..). (±)Sulpiride (40,80 mg·kg -1 , sc), a kind of D 2 receptor antagonist, also blocked the CPP effect of MA(2 mg·kg -1 ). The antagonism of both antagonists were in the dose dependent manner. Conclusion: MA could induce CPP effect in rats, showing that it had psychic dependence potency. Both D 1 and D 2 receptors were both involved in MA induced place preference.