期刊文献+

血栓抽吸导管联合半剂量替罗非班治疗老年急性ST段抬高性心肌梗死的研究 被引量:4

下载PDF
导出
摘要 目的评价老年急性ST段抬高性心肌梗死(STEMI)在急诊冠状动脉介入治疗时血栓抽吸导管联合半剂量替罗非班的效果及安全性。方法将63例老年STEMI患者随机分为血栓抽吸+替罗非班组(观察组)和标准经皮冠状动脉介入治疗组(对照组)。观察两组术后TIMI血流、心电图ST段回落>50%、左室舒张末期内径(LVDd)、左室射血分数(LVEF)及术后4周主要心血管事件和出血并发症。结果观察组TIMI 3级血流、心电图ST段回落>50%的发生率及LVEF高于对照组,心肌酶达峰时间和LVDd低于对照组(P<0.05)。两组患者住院期间主要心血管事件和出血发生率比较差异无统计学意义(P>0.05)。结论血栓抽吸导管联合半剂量替罗非班治疗老年STEMI有效且安全性较好。
出处 《山东医药》 CAS 北大核心 2010年第48期93-94,共2页 Shandong Medical Journal
  • 相关文献

参考文献7

  • 1Keeley EC,Boura JA,Grines CL.Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction:a quantitative review of 23 randomized trials[J].Lancet,2003,361(9351):13-20.
  • 2Schmig A,Kastrati A,Dirschinger J,et al.Coronary stenting plus platelet glycoprotein Ⅱb/Ⅲa blockade compared with tissue plasminogen activator in acute myocardial infarction[J].N Engl J Med,2000,343(6):385-391.
  • 3Kastrati A,Mehilli J,Dirschinger J,et al.Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction:a randomized trial[J].Lancet,2002,359(9310):920-925.
  • 4Ellis SG,Tendera M,de Belder MA,et al.Facilitated PCI in patients with ST-elevation myocardial infarction[J].N Engl J Med,2008,358(21):2205-2217.
  • 5Mehilli J,Kastrati A,Schulz S,et al.Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading:a randomized double-blind trial[J].Circulation,2009,119(14):1933-1940.
  • 6Valgimigli M,Campo G,Percoco G,et al.Comparison of angioplasty with infusion of tirofiban or abciximab and with implantation of sirolimus-eluting or uncoated stents for acute myocardial infarction:the MULTISTRATEGY randomized trial[J].JAMA,2008,299(15):1788-1799.
  • 7Thygesen K,Alpert JS,White HD,et al.Universal definition of myocardial infarction[J].Circulation,2007,116(22):2634-2653.

同被引文献44

  • 1Grines CL, Browne KF, Marco J, et al. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group [ J ]. N Engl J Med, 1993, 328 (10) : 673 -679.
  • 2Napodano M, Bamondo A, Tarantini G, et al. Predictors and time - related impact of distal embolization during primary angioplasty [ J ]. EurHeartJ, 2009, 30 (3): 305-313.
  • 3Fokkema ML, Vlaar PJ, Svilaas T, et al. Incidence and clinical con- sequences of distal embolization on the coronary angiogram after percuta- neous coronary intervention for ST - elevation myocardial infaretion [ J ]. Eur Heart J, 2009, 30 (8): 908-915.
  • 4Zijlstra F, de Boer MJ, Hoorntje JCA, et al. A comparison of immedi- ate coronary angioplasty with intravenous streptokinase in acute myocardi- al infarction [J]. N Engl J Med, 1993, 328 (10) : 680 -684.
  • 5Yang CT, Hwang JJ, Lin LC, et al. Initial thrombosuction with subse- quent angioplasty in primary coronary intervention -comparison with conventional strategy [ J]. Int J Cardiol, 2005, 102 ( 1 ) : 121 - 126.
  • 6Chao CL, Hung CS, Lin YH, et al. Time - dependent benefit of ini- tial thrombosuction on myocardial reperfusion in primary percutaneous coronary intervention [ J ]. Int J Clin Pract, 2008, 62 ( 4 ) : 555 - 561.
  • 7Svilaas T, Vlaar PJ, van der Horst IC, et al. Thrombus aspiration dur- ing primary percutaneous coronary intervention [ J ]. N Engl J Med, 2008, 358 (6): 557-567.
  • 8Brener SJ, Barr LA, Burchenal JE, et al. Randomized, placebo - controlled trial of platelet glycoprotein II b/III a blockade with primary angioplasty for acute myocardial infarction [ J]. Circulation, 1998, 98 (8) : 734 -741.
  • 9Montalescot G, Antoniucci D, Kastrati A, et al. Abciximab in primary coronary stenting of ST - elevation myocardial infarction: a European meta - analysis on individual patients' data with long - term follow - up [J]. EurHeartJ, 2007, 28 (4): 443-449.
  • 10Liu CP, Lin MS, Chiu YW, et al. Additive benefit of glycoprotein II b/IIIa inhibition and adjunctive thrombus aspiration during primary coronary intervention: results of the Initial Thrombosuction and Tiwfiban Infusion (ITTI) trial [J]. Int J Cardiol, 2012, 156 (2): 174- 179.

二级引证文献30

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部