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肝癌组织中β-catenin和核PTEN的表达及其与病理学特征关系研究

The expression and pathological role of β-catenin and PTEN proteins in primary hepatocellular carcinoma
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摘要 目的研究肝癌组织中β-catenin和PTEN蛋白的表达及其与临床病理学特征之间的关系。方法应用免疫组织化学染色法对64例原发性肝癌组织、9例肝硬化组织、5例正常肝组织中β-catenin和PTEN的表达情况进行检测,结合肝癌的临床病理学特征进行分析。结果原发性肝癌(HCC)中β-catenin蛋白的异常表达率为68.8%(44/64),与肝硬化和正常肝组织相比,有显著性差异(P<0.05);PTEN蛋白的核阳性表达率为53.1%(34/64),与肝硬化及正常肝组织相比无显著性差异。HCC低分化组的β-catenin异常表达率高于中高分化组,而核PTEN的表达无显著性差异(P>0.05)。结论β-catenin的异常表达和HCC的发生及分化密切相关。 Objective To investigate pathological role of β-catenin and phosphatase and tension homologue(PTEN) in the primary hepatocellular carcinoma(HCC).Methods Immunohistochemistry(S-P method) was adopted to detect the expressions of β-catenin and PTEN proteins in 64 HCC,9 liver cirrhosis and 5 normal liver specimens.Results The aberrant expression rate of β-catenin protein was 68.8%(44/64)in HCC,higher than that in liver cirrhosis 33.3%(3/9) and normal liver tissues 20%(1/5).The positive expression rate of PTEN protein was 53.1%(34/64) in HCC.The aberrant expression rate of β-catenin in the low differentiation group were higher than them in the high differentiation group(P 〈0.05).Conclusion Aberrant expression of β-catenin protein was associated with the occurrence and differentiation of HCC.
出处 《北京医学》 CAS 2010年第12期983-986,共4页 Beijing Medical Journal
基金 北京市教委科技发展计划项目(KM200910025002)
关键词 Β-连环素 PTEN蛋白 原发性肝癌(HCC) 免疫组织化学S-P法 Primary hepatocellular carcinoma(HCC) β-catenin PTEN protein Immunohistochemistry
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