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高密度脂蛋白修饰后功能障碍与动脉粥样硬化的关系 被引量：1

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摘要 高密度脂蛋白（HDL）是血浆中具有抗动脉粥样硬化（atherosclemsis，AS）作用的脂蛋白，主要生理功能是介导胆固醇的逆向转运。此外，还具有抗炎、抗氧化、抗血栓形成和保护内皮等功能。然而，近年大量研究表明，体内的HDL可被修饰，导致其功能障碍。冠心病、糖尿病、全身性炎症、高饱和脂肪酸饮食与HDL修饰相关。修饰后的HDL抗AS作用减弱，还通过多种途径加速AS的发生和发展。现就HDL的修饰机制和修饰后结构、功能的改变进行综述。
作者 刘峰涛 姜志胜
机构地区 南华大学心血管病研究所 动脉硬化学湖南省重点实验室
出处 《中国心血管杂志》 2010年第6期476-478,共3页 Chinese Journal of Cardiovascular Medicine
基金 国家自然科学基金项目(30971169) 湖南省普通高校科技创新团队和南华大学留学归国人员科研启动基金资助
关键词 抗动脉粥样硬化 高密度脂蛋白 功能障碍 修饰后 抗血栓形成 全身性炎症 饱和脂肪酸 HDL
分类号 R543 [医药卫生—心血管疾病]
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参考文献24

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共引文献6

同被引文献15

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引证文献1

中国心血管杂志
2010年 第6期

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