糖尿病下肢动脉病变相关危险因素分析

The risk factors of peripheral arterial disease in diabetes mellitus

目的:通过对比研究2型糖尿病不同程度糖尿病下肢动脉血管病变组(PAD组)及NPAD组患者相关生化指标,阐明其在糖尿病下肢动脉病变发生发展中的作用,为临床治疗提供理论依据和方向。方法:2型糖尿病患者63例,进行AB I的测定,按测定的结果分为PAD组和NPAD组,检测PAD相关危险因素。结果:两组一般资料比较,体重指数(BM I)、舒张压(DBP)差别无统计学意义(P>0.05);年龄、病程、收缩压(SBP)、脉压差的差别均有统计学意义(P<0.05)。两组总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)差别均无统计学意义(P>0.05),低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、空腹血糖(FBG)、餐后2小时血糖(PBG2h)差别均有统计学意义(P<0.05)。结论:LDL-C、TG、FBG、PBG2h是PAD的重要危险因素,与PAD严重程度密切相关,应成为今后临床工作中的重要检测指标。

Objective： To obtain the risk factors changes of PAD.Through comparing the two type diabetes ankle-brachial artery disease lesions group（PAD group） with the risk factors of patients in NPAD group to clarify its effects at the period of the occurrence and development of lesions in ankle-brachial artery disease with diabetes and provide a theoretical basis and direction of clinical treatment.Methods： We selected 63 diabetics,and then ABI were examined in these 80 patients.According to the results,the patients were divided into two groups,including group PAD and group NPAD.All patients are measured the risk factors of PAD.Results： Through comparing the data of PAD group and NPAD group,the differences of BMI and diastolic blood pressure（DBP） have no statistical meaning because P0.05,on the contrasty,the differences in age,duration,systolic blood pressure（SBP）and pulse pressure have statistical meaning（P0.05）.Through the biochemical data of PAD group and NPAD group： The differences in TC,HDL-C,PT and APTT have not statistical meaning while TG,LDL-C,FBG and PBG2h have statistical meaning（P0.05）.Conclusion： LDL-C,TG,FBG and PBG2h is an important risk factor for PAD,which is closely related to the severity of PAD.in the future,which correlates with the risk factors of cardiovascular disease.