中药秦艽抗炎镇痛作用的实验研究

Analgesic and anti-inflamed effects study of Radix Gentianae Macrophyllae

目的研究中药秦艽的抗炎镇痛作用。方法用醋酸扭体法、热板法观察秦艽水煎液对小鼠的镇痛作用;用二甲苯致小鼠耳廓肿胀、角叉菜胶致足跖肿胀的方法观察秦艽水煎液的抗炎作用。结果秦艽水煎液30g/kg能减少小鼠扭体次数,提高小鼠痛阈值(P<0.01),明显抑制小鼠耳廓肿胀和足跖肿胀(P<0.01)。结论秦艽具有一定的抗炎、镇痛作用。

Objective To study the analgesic and anti-inflamed effects of Radix Gentianae Macrophyllae. Methods Hot plates and writhing test were employed to observe the analgesic effects of Radix Gentianae Macrophyllae in mice. Ear swelling caused by Dimethyl benzene and hind paw swelling caused by carrageenan for observing the anti-inflamed effects of Radix Gentianae Macrophyllae. Results Radix Gentianae Macrophyllae decoction could reduce the writhing times and improve threshold of pain of mice （P0.01）,and inhibit the ear swelling and hind paw swelling significantly（P0.01）. Conclusion Radix Gentianae Macrophyllae has analgesic and anti-inflamed effects.