新的N-苯并噻唑基香豆素酰胺类化合物的合成及光谱特性

Synthesis and spectral properties of new coumarin formamides

用具有光学活性和生物学活性的2类化合物(取代)香豆素-3-甲酰氯和2-氨基苯并噻唑作用合成了4种新的兼具香豆素骨架和苯并噻唑基的化合物(3a-3d),用HRMS,IR和1H NMR对化合物结构进行了表征,确定了化合物的结构,并对其紫外吸收光谱和荧光光谱与分子结构的关系进行了讨论.研究发现:在紫外光谱中,新化合物(3a-3d)和2种原料化合物相比,因共轭链的增长而使其最大吸收波长(λmax)红移;4种化合物表现出比原料化合物较强的荧光性能,其中3c的荧光强度最大.文中给出了稀溶液中紫外光谱和荧光光谱相关的一些信息.

To derign the better optical and biologyical activity compounds,four new compounds（3a～3d）of coumarin formamides were synthesized from substituted coumarin-3-formylchlorides and 2-aminobenzothiazole.The structures of title compounds were characterized by HRMS,1H-NMR and FT-IR.The relations between the UV spectra and the fluorescent spectrum and molecular structures of 3a～3d were studied.The result indicates that the new compounds have longer maximum absorption wavelength in the UV spectrum and exhibit stronger fluorescent emission in the fluorescent spectrum than the original materials because of the increasing conjugation system.