络达秦治疗急性脑梗死的临床研究

Clinical observations of Luodaqin in the treatment of acute cerebral infarction

目的:研究络达秦治疗急性脑梗死的疗效。方法:随机选择颈内动脉系统急性脑梗死患者42例为治疗组静滴络达秦80mg,40例为对照组静滴丹参注射液20ml,1次/d,持续10d,治疗组患者治疗前后做血液流变学检查。结果:络达秦治疗后神经功能缺损积分减少及生活能力等级与治疗前比较差异有统计学意义(P<0.01),与对照组相比差异也有统计学意义(P<0.01),血液黏度及血小板聚集率下降(P<0.01),而纤维蛋白原无明显变化。结论:络达秦是治疗急脑梗死的一种安全有效的药物。

Objective To study the effect of Luodaqin （Ligustrazine Hydrochloride and Sodium Chloride Injection ） in the treatment of acute cerebral infarction.Method Forty-two patients with acute cerebral infarction in internal carotid artery were selected randomly and treated with Luodaqin of 80 mg for intravenous drip,forty patients were selected as control subjects and treated with Danshen Injection of 20 ml for intravenous drip.The treatment for both groups was a ten-day course of one dose a day.Patients of Luodaqin treated group were tested hemorheology.Results After the treatment with Luodaqin,the dysfunction of nervous system and the living ability of the patients had been improved significantly （P0.01）,there was significant difference in the therapeutic effect compared with the control group （P0.01）,the viscosity of whole blood and the platelet aggregation rate had decreased （P0.01）,yet there was no obvious difference of changes in fibrinogen.Conclusion Luodaqin has a good and safe therapeutic effect on treating acute cerebral infarction.