奥扎格雷联合低分子肝素治疗急性脑梗死疗效观察

Clinical study on ozagrel combined with low molecular weight heparin in the treatment of acute cerebral infarction

目的观察奥扎格雷联合低分子肝素治疗急性脑梗死的临床效果及安全性。方法 48例急性脑梗死患者随机分为观察组和对照组各24例。对照组给予常规治疗,观察组在对照组基础上给予奥扎格雷联合低分子肝素治疗。观察2组治疗前、后血流变、神经功能缺损程度评分(NDS)情况及观察组凝血功能变化。结果观察组治疗后第7、14天的NDS均高于对照组,血液流变学情况优于治疗前,差异有统计学意义(P<0.05)。观察组治疗前、后凝血功能指标无变化,差异无统计学意义(P>0.05)。结论奥扎格雷联合低分子肝素治疗急性脑梗死有助于神经功能恢复,抑制病情进展,具有良好的安全性,值得临床推广。

Objective To observe the clinical effect and safety of ozagrel combined with low molecular weight heparin （LMWH） in the treatment of acute cerebral infarction.Methods 48 cases were randomly divided into observation group and control group,24 cases of each.The control group was given traditional treatment,while the observation group based on the control group was treated with ozagrel combined with LMWH.The situation of hemorheology and neurological deficits score（NDS） of 2 groups,as well as the changes of coagulation function were observed before and after treatment.Results 7 days and 14 days after treatment,NDS of the observation group was respectively higher than that of the control group,while the situation of hemorheology was better than that before treatment,and all the differences were statistically significant（P0.05）.After treatment,there was no change of indexes of coagulation function in the observation group,and the difference was of no statistical significance（P0.05）.Conclusion Treating acute cerebral infarction with ozagrel combined with LMWH is beneficial to the recovery of nerve function,which can also inhibit the progress of the disease with favorable safety,so it is worh clinical popularizing.