药物不良反应263例报告分析

Analysis of 263 adverse drug reaction case reports

目的了解药物不良反应(ADR)发生情况,并探讨其发生因素。方法对2007-2008年上报的263例ADR报告按年龄、性别、给药途径、药物种类、临床表现等方面进行回顾性统计、分析。结果 263例ADR报告中,男、女比例基本平衡;以<10岁和>60岁的患者居多;静脉给药是引起ADR的主要给药途径;涉及药物165种,以抗生素居多,其次为中药注射剂;临床表现以皮肤及附件损伤最为常见;严重的ADR报告13例(4.94%)。结论加强ADR监测工作,以避免或减少ADR的发生,确保临床安全合理用药。

Objective To investigate the occurrence situation of adverse drug reaction （ADR） in our hospital,and to explore its factors.Methods 263 ADR reports in our hospital in 2007～2008 were statistically and retrospectively analyzed from respects of patients＇ age,sex,route of administration,drug categories,specific clinical manifestations,and so on.ResultsOf the total 263 ADR cases,the ratio of male was equal to that of female; The majority were below 10 years old and above 60 years old;The main route of administration that induced ADR was intravenous route; There were 165 kinds of drugs that were involved,and the majority were antibiotic,a second concern was chinese medicine injection;The most common clinical manifestations were the damage of skin and its accessories;There were 13 case reports （4.94%） which were severe ADR.Conclusion More attention should be paid to the monitoring,so as to lessen or avoid the occurrence of ADR and ensure safety and rationality of drug use in clinic.