摘要
目的观察和探讨新型肿瘤标志物细胞角蛋白18片段（CKl8—3A9）血清水平对胃癌的诊断价值。方法采用化学发光法检测并比较350例胃癌、150例胃炎和500名健康体检者空腹血清中CKl8—3A9水平，对比血清CKl8-3A9与CA72—4水平对胃癌的诊断效果。结果CKl8—3A9诊断胃癌灵敏度为46．29％，特异度为96．92％；CA72—4灵敏度为26．00％，特异度为93．23％。CKl8—3A9灵敏度和特异度明显高于CA72—4（P〈0．001）。结论新型肿瘤标志物CKl8-3A9血清水平检测对胃癌能起到临床辅助诊断的作用。
Objective To investigate the diagnosis value of a new tumor marker CK18-3A9 in gastric cancer patients. Methods The serum level of CK18-3A9 in 350 gastric cancer patients, 150 gastritis patients and 500 healthy controls was detected with chemoluminescence, the diagnosis efficacy between the serum CK18-3A9 and CA72-4 was compared. Results The sensitivity, specificity of CK18-3A9 were 46.29 % and 96.92 %, but the sensitivity, specificity of CA72-4 were 26.00 % and 93.23 %, respectively. The differences were significant （P 〈0.001）. Conclusion The serum level of CK18-3A9 maybe a new auxiliary diagnosis marker for gastric cancer.
出处
《肿瘤研究与临床》
CAS
2010年第11期733-735,共3页
Cancer Research and Clinic
