稳心颗粒在慢性心力衰竭患者治疗中的价值探讨

Effect of Wenxin Granule on chronic heart failure

目的:通过观察稳心颗粒(党参、黄精、三七、琥珀和甘松)对慢性心力衰竭(CHF)患者左室射血分数(LVEF)和血浆脑钠肽(BNP)水平的影响,探讨稳心颗粒在CHF患者治疗中的价值。方法:将98例CHF随机分为治疗组50例和对照组48例,对照组常规给予利尿剂、洋地黄制剂、血管紧张素转换酶抑制剂(ACEI)、β-受体阻滞剂等治疗。治疗组在以上常规给药的基础上加用稳心颗粒,9 g/次,3次/d,8周为1个疗程。全部病例均在治疗前和1个疗程结束后测定血浆BNP和LVEF。结果:治疗组患者治疗前后血浆BNP水平、LVEF比较,差异均有统计学意义(P<0.05);对照组治疗前后血浆BNP水平比较,差异有统计学意义(P<0.05),但LVEF比较,差异无统计学意义(P>0.05)。两组患者间治疗后血浆BNP水平、LVEF比较,差异均有统计学意义(P<0.05)。结论:稳心颗粒可以有效改善CHF患者的心功能指标,在CHF患者的治疗中具有一定的临床价值。

AIM： To observe the effect of Wenxin Granule（Radix codonopsis;Rhizoma polygonati;Radix et Rhizoma notoginseng;Amber;Radix et Rhizoma nardostachyos） on brain natriuretic peptide（BNP） level in blood plasma and left ventricular ejection fraction（LVEF） in patients with chronic heart failure.METHODS： Ninety-eight patients with chronic heart failure were randomly divided into control group（n = 48） and therapy group（n = 50）.The control group was treated with diuretic,digitalis,angiotensin converting enzyme inhibitor（ACEI） and β-receptor blocker.The therapy group was treated with Wenxin Granule（9.0 g,three times one day） for 8 weeks and based on the same treatment of the control group.The BNP level in blood plasma and LVEF were detected before treatment and the end of course of treatment.RESULTS： Compared with the control group,the level of BNP in blood plasma and LVEF in the therapy group showed statistical difference after a course of treatment（P 〈 0.05）.Compared with before treatment,the level of BNP in blood plasma and LVEF after a course of treatment showed sig-nificant difference in therapy group（P 〈 0.05）.CONCLUSION： Wenxin Granule can effectively improve the heart functional parameter in patients with chronic heart failure.There are some beneficial effects of Wenxin Gran-ule on patients with chronic heart failure.