摘要
目的:制备黄藤素微丸,并对其制备工艺进行研究。方法:采用正交试验设计,筛选出黄藤素微丸的最佳制备工艺,并优化微丸的包衣工艺,增强制剂稳定性。结果:筛选出的最佳工艺条件为A3B3C3,即蒸馏水用量215g/1 000粒、滚圆速度32Hz、微晶纤维素用量33%,成功地制备了黄藤素微丸;包衣最佳工艺条件如下:采用爱勒易包衣粉、包衣液浓度14%、包衣增重4%,黄藤素微丸经薄膜包衣后,增强了微丸的抗湿性。结论:本工艺科学合理,制剂稳定。
Objective：To prepare and research Palmatine pellets.Methods：According to the orthogonal experimental design,and selected the best palmatine pellets preparation,and optimize the coating process pellets,and enhance the stability of preparations.Results：The optimum conditions were screened out as A3B3C3,which was distilled water（215g/1 000 tablets）,spheronization machine frequency（32Hz）and microcrystalline cellulose（33%）,Palmatine pellets were successfully prepared;The optimized coating conditions were established as follows;ILE coating powder,coating concentration（14%）,coating weight（4%）,Palmatine pellets were coated,Palmatine pellets enhanced the anti-wet.Conclusion：The process was scientific and rational.
出处
《云南中医学院学报》
2010年第6期31-34,共4页
Journal of Yunnan University of Traditional Chinese Medicine
关键词
黄藤素
微丸
正交实验
palmatine
pellets
orthogonal experiment
