14例自身免疫性胰腺炎的临床研究

Autoimmune pancreatitis clinical research in 14 cases

目的探讨自身免疫性胰腺炎(autoimmunepancreatitis,AIP)的临床诊断和治疗。方法对14例AIP患者诊治进行回顾性分析。结果 14例AIP患者多以黄疸、腹痛、消化不良为主要临床表现,可有血清γ球蛋白、IgG升高和自身免疫抗体的改变,MRI可显示胰腺弥漫或局限性肿大、胰管狭窄及内部信号异常改变,13例应用泼尼松治疗,11例取得良好疗效。结论 AIP患者具有特有的临床体征、生化等表现,对激素作用敏感,预后较好。

Objective To explore autoimmunepancreatitis autoimmune pancreatitis（AIP）,the clinical diagnosisand treatment.Methods Of 14 cases of patients with AIP treatment were analyzed retrospectively.ResultsPatients with more than 14 cases AIP jaundice,abdominal pain,indigestion as major clinical manifestations,have elevated serum gamma globulins,IgG and autoimmune antibodies can be changed,MRI showed diffuseenlargement,or limitation of pancreatic duct stenosis,and internal signal abnormal changes,13 cases ofapplication prednisone treatment,10 cases obtained satisfactory effect.Conclusion The patients with uniqueAIP clinical signs,biochemical,for hormone sensitive,prognosis is good.