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GLP-1及其类似物与2型糖尿病的关系 被引量：5

Advances on GLP-1 and analogs for type 2 diabetes
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摘要 2型糖尿病发病机制为胰岛素抵抗和胰岛β细胞功能逐渐下降。大量研究表明胰高血糖素样肽-1（Glucagon-Like Peptide 1,GLP-1）具有降血糖、促胰岛素分泌的功能。有研究甚至显示GLP-1的作用缺陷从而引起β细胞功能障碍可能是导致个体发展为2型糖尿病的重要原因。国内也有通过对大鼠研究认为：在大鼠模型中糖尿病发生、发展可能与胰腺的GLP-1受体表达下调有关。
作者 张月华
机构地区 武警浙江总队医院内分泌科
出处 《武警医学院学报》 CAS 2010年第11期921-924,共4页 Acta Academiae Medicinae CPAPF
关键词 GLP-1 GLP-1类似物 2型糖尿病
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献20

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二级参考文献11

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共引文献9

同被引文献67

  • 1刘素芳,陈屏,许继田,王清勇,姚运纬.GLP-1(7-36)NH_2的促胰岛素分泌作用和胞内cAMP浓度改变与胰岛素mRNA表达[J].中国应用生理学杂志,2004,20(3):217-218. 被引量：6
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引证文献5

二级引证文献28

武警医学院学报
2010年 第11期

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