体检人群超敏C反应蛋白水平与非高密度脂蛋白胆固醇和血浆致动脉硬化指数相关性研究

Correlation between atherogenic index of plasma (AIP) and values of high sensitivity CRP (hs-CRP) and non-high density lipoprotein cholesterol (non-HDL-C) among the residents taking physical examination

目的探讨体检人群超敏C反应蛋白(hs-CRP)水平与血浆致动脉硬化指数(AIP)、非高密度脂蛋白胆固醇(non-HDL-C)水平相关性及临床意义。方法随机选择从2004年1月～2009年12月在温州医学院附属第一医院体检中心参与体检的12 062例人员,测定甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、hs-CRP,计算出non-HDL-C、AIP;并按hs-CRP水平及性别进行分组。数据采用SPSS13.0统计软件,组间比较用t检验,P<0.05为差异有统计学意义。结果该研究人群hs-CRP异常率为58.2%(7 020/12 062),男性hs-CRP异常率66.4%(4 040/6 081)明显高于女性49.8%(2 981/5 981)(χ2=1 063.16,P=0.000),hs-CRP水平也存在明显性别差异;在男性人群中,随hs-CRP水平升高,研究指标中仅AIP水平出现增高(F=4.111,P=0.017),相关分析显示hs-CRP仅与AIP呈正相关(r=0.114,P=0.047);在女性人群中,随hs-CRP水平升高,TG、HDL-C、non-HDL-C、AIP、低密度脂蛋白胆固醇(LDL-C)水平出现增高(F=14.351、4.722、6.119、16.825、3.233,P=0.000、0.010、0.002、0.000、0.041),相关分析显示hs-CRP与TG、AIP呈正相关(r=0.162、0.200,P=0.005、0.000),与HDL-C呈负相关(r=-0.121,P=0.036)。结论 hs-CRP水平有明显性别差异,男性hs-CRP异常率明显高于女性;hs-CRP与AIP有正相关,而与non-HDL-C无明显相关性;联合检测AIP、hs-CRP比其他血脂指标可能更好地预测价值,反映健康人群首发心血管事件。

Objective To analyze the correlation between atherogenic index of plasma（AIP） and values of high sensitivity CRP（hs-CRP） and non-high density lipoprotein cholesterol（non-HDL-C） among the residents taking physical examination.Methods The 12 062 residents of Wenzhou city aged 21-71 years had physical examination and blood testing between 2004 and 2009.The blood samples were tested for the concentrations of hs-CRP,TG,TCH,and HDL.AIP and non-HDL-C values were also calculated.Results The abnormal rates of hs-CRP were 58.2%（7 020/12 062） on average,78.31%（4 762/6 081） in male and 49.84%（2981/5981） in female participants.There was a significant difference in hs-CRP level between men and women（χ2=1 063.16,P0.05）.The elevated level of hs-CRP was only associated with the increased level of AIP（F=4.111,P=0.017）among all the tested and calculated indexes in male participants.A correlation analysis also showed a positive relationship between hs-CRP and AIP（Pearson coefficient=0.114,P=0.047）in men.However,the elevated level of hs-CRP was associated with the increased levels of TG,HDL-C,non-HDL-C,AIP,LDL-C（P〈0.05） in female participants.The level of hs-CRP had positive correlation with the levels of TG（Pearson coefficient=0.162,P〈0.05）and AIP（Pearson coefficient = 0.200,P〈0.05）,but negative correlation with the level of HDL-C（Pearson coefficient=-0.121,P〈0.05）.Conclusion The abnormal rate of hs-CRP was significantly higher in men than that in women.The level of hs-CRP was correlated with the level of AIP.The combination of hs-CRP and AIP makes better predictor for cardiovascular events.