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多发性骨髓瘤与白细胞介素-6 被引量：1

Multiple myeloma and interleukin-6
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摘要 白细胞介素-6是多发性骨髓瘤(multiple myeloma,MM)瘤细胞生长和生存的关键因子,也是MM患者发病的主要因子。IL-6/IL-6R系统通过不同通路影响多发性骨髓瘤瘤细胞生长并导致患者骨损害、类风湿性关节炎等一系列并发症。针对IL-6/IL-6R系统的治疗方法将给MM的治疗带来重大的进展。 Interleukin-6 is a key growth and survival factor,which is involved in tumorigenesis of multiple myeloma.The proliferation of malignant cells in multiple myeloma are affected through different pathways of IL-6/IL-6R,which also could lead to bone damage,rheumatoid arthritis and some other complications in patients.Treatment of MM targeted IL-6/IL-6R system will provide a new therapeutic approach based on interruption of IL-6 mediated tumor cell growth in future.
作者 王建军 洪丽萍 汤立军
机构地区 中南大学生物科学与技术学院分子生物学研究中心
出处 《生命科学》 CSCD 北大核心 2010年第11期1192-1195,共4页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(30400529) 湖南省杰出青年基金(04JJ1006) 中南大学米塔尔学生创新基金资助项目(08MX26)
关键词 IL-6/IL-6R GP130 多发性骨髓瘤 IL-6/IL-6R gp130 multiple myeloma
分类号 R551.3 [医药卫生—血液循环系统疾病] R733.3 [医药卫生—肿瘤]
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参考文献22

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同被引文献28

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  • 9Hashizume M, Mihara M. High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1 [J]. Biochem Biophys Res Commun, 2010, 403 (2): 184-189.
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生命科学
2010年 第11期

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