某院1137份国家基本药物不良反应报告分析与评价

Analysis and Evaluation of 1 137 ADR Reports of National Essential Drugs in a Hospital

目的:了解某"三甲"医院应用的国家基本药物不良反应的特点,为临床合理使用该类药物提供参考。方法:从该院2007年1月1日～2009年12月31日医务人员自愿呈报的药品不良反应(ADR)报告中整群抽取国家基本药物相关报告,进行描述性分析与评价。结果:该院3年共收到国家基本药物相关ADR报告1137份,占报告总数的19.65%,其中新的ADR报告为442份,严重的ADR报告77份;给药途径以静脉滴注为主(88.21%);抗微生物药物所占比例最高(48.72%),中成药为4.93%;ADR临床表现以皮肤及其附件损害最常见(33.52%);94.28%的ADR对原患疾病无影响;99.47%能治愈或好转。结论:应加强对国家基本药物ADR的监测,保证患者用药安全、有效。

OBJECTIVE：To find out the characteristics of adverse drug reactions（ADR） induced by national essential drugs in one class A grade three hospital,and to provide reference for rational use of essential drugs.METHODS：The ADR reports of national essential drugs were reported by medical staff in our hospital during Jan.1 2007 to Dec.31 2009.Reported cases were analyzed descriptively and evaluated.RESULTS：In 3 years,1 137 ADR cases of national essential drugs were received and accounted for 19.65% of total numbers,containing 442 new ADR reports and 77 severe ADR ones.Intravenous dripping infusion was main route of administration（88.21%）.48.72% ADR cases were induced by anti-infective drugs,which occupied the maximum proportion.Chinese patent medicine was 4.93%.Main clinical manifestations were lesion of skin and its appendants（33.52%）;94.28% had no influence on original illness and 99.47% were able to be healed or changed for the better through treatment or abandoning taking medicine.CONCLUSIONS：Great importance should be attached to ADR monitoring to guarantee the safety and effectiveness of drug use.