雷公藤甲素对异种神经移植后神经再生的影响

THE EFFECT OF CUTTING INFUNDIBULUM ON THE WALL OF AORTA

目的探讨雷公藤甲素对异种神经移植后神经再生的影响。方法将日本大耳兔的神经移植于Ｗｉｓｔａｒ大鼠坐骨神经后，宿主服用雷公藤甲素。结果大鼠存活４、８、１２、１６、２４周，可见再生神经纤维长入移植神经并向远段坐骨神经生长。移植神经和远段神经内的再生神经纤维中有髓纤维和无髓纤维兼有之，大部分再生神经纤维聚集成束。术后１２周的腓肠肌ＡＣｈＥ呈阳性，并可见再生神经纤维与运动终板相连。１２周以后的爪部皮下出现再生神经束，真皮层出现游离神经末梢。未服用雷公藤甲素的对照组因免疫排斥反应而神经不能再生。

Objective\ To study the passage of the regular control of the hypothalamus to blood vessel.Methods\ Twelve Wistar rats were used as experimental group and six as cotrol group.The experimental group was given an operation of cutting infundibulum and the contol group was given an exposure of not cutting the infundibulum.Both groups were raised under similar condition.After surviving for 30 days,the animals were killed and specimens from aorta were taken and observed under light and electron microscope.Results\ After cutting infundibulum,the degeneration of endothelial cells with edematous nucleus could be seen.There were vesicles of various sizes in the thickened subendothelial tissue.The proliferative collagenous fibers were aslo observed around ruptured myo endothelial junction.The structure of the control group remained intact.Conclusion\ This study indicated that the intact of endothelium might be dependent on the regular control of the hypothalamus,which is realized by the passage from hypothalamus to hypophyis.