尿毒症患者发生颈动脉重构的危险因素分析

Analysis on the risk factors of carotid reconstruction a uremia patient may face

目的采用颈动脉内膜-中层厚度来评价颈动脉重构程度，分析尿毒症患者发生颈动脉重构的危险因素。方法采用回顾性队列研究，选取维持性血液透析的尿毒症患者120例，按有无动脉重构分为颈动脉重构组（A组，n=74例），非颈动脉重构组（B组，n=46例），分别评价两组患者年龄、血压、吸烟、脉搏波传导速度及生化指标。结果采用二分类的非条件Logistic回归多因素方法，筛选出5个危险因素：收缩压（OR=1．85）、吸烟（OR＝1．77）、年龄（OR=1．74）、甘油三酯（OR=1．08）、总胆固醇（OR=1．05）,上述指标回归系数均为正值，差异有统计学意义（P〈0．05）。结论收缩压、吸烟、年龄、甘油三酯、总胆固醇可能是尿毒症患者发生颈动脉重构的危险因素。

Objective To analyze the risk factors of carotid reconstruction in end-stage renal disease （EDRS） patients under hemodialysis may face, adopt carotid artery intima-media thickness to evaluate the degree of carotid reconstruction. Methods 120 EDRS patients under hemodialysis were divided into the two groups- A group （74 patients with artery remodeling group） and B group （46 patients with non-artery remodeling group）. The evaluation was made with following criteriaage, blood pressure, smoking, and biochemical indicators. Results Using two categories of rion-condition logistic regression multivariate methods, filter out the five risk factors as systolic blood pressure （OR = 1.85）, smoking （OR = 1.77）, age （OR = 1.74）, triglyceride （OR = 1.08）, and the total cholesterol （OR = 1.05）. The overall regression coefficients reflected positive （P〈 0.05）. Conclusion The systolic blood pressure, smoking, age, triglyceride, and the total cholesterol may he the risk factors, interrelated with EDRS patients＇ carotid reconstruction.