不同ABO血型病人自控静脉镇痛药物用量的比较

Comparison of consumption of drugs for patient-controlled intravenous analgesia in patients with different blood groups

目的比较不同ABO血型病人自控静脉镇痛的药物用量。方法择期全麻下行子宫肌瘤剔除术或子宫全切术病人100例，年龄30～50岁，ASA分级Ⅰ或Ⅱ级，体重指数〈30kg／m^2，根据血型分为A组（n=25）、B组（n：30）、AB组（n=11）和O组（n=34）。手术结束前30rain静脉注射氟比洛芬酯lmg／kg，术毕时静脉注射舒芬太尼，VAS评分≤4分时行病人自控静脉镇痛，镇痛药物为舒芬太尼1．2μg／ml，背景输注速率0．5ml／h，PCA量2．0ml，锁定时间5min。记录舒芬太尼的负荷量和术后第1、2天的用量。结果舒芬太尼负荷量和术后第1天用量A组和B组最高，AB组次之，O组最低（P〈0．05）。结论不同ABO血型病人自控静脉镇痛药物用量存在差异。

Objective To compare the consmnption of the drugs for patient-controlled intravenous analgesia （PCIA） in patients with difierent blood groups. Methods One hundred female ASA Ⅰ orⅡpatients, aged 30-50 yr, body mass index 〈 30 kg/m^2 , scheduled for elective total hysterectomy or myomectomy, were enrolled in this study. The patients were divided into 4 groups according to the blood group： group A （ n = 25）, group B （ n = 30）, group AB （ n = 11 ） and group O （ n = 34）. Patients received iv injection of flurbiprofen 30 rain before the end of surgery and sufentanil at the end of surgery. PCIA with sufentanil 1.2 μg/ml （bolus dose 2.0 ml, back- ground infusion 0.5 ml/h, lockout interval 5 min） was performed when the VAS score ≤4. The loading dose and consumption on 1st and 2nd day after operation for sufentanil were recorded. The adverse reactions were observed. Results The loading dose and consumption on 1 st day after operation for sufentanil were the highest in group A and B, the second in group AB, and the lowest in group O among the 4 groups. Conclusion The consumption of the drugs for PCIA is different in patients with different blood groups.