黄芪注射液对肝门阻断后肝功能损害的治疗作用

Protective effect of astragalus membranaceus on hepatic injury after hepatic portal vascular occlusion

目的探讨黄芪注射液对肝门阻断后肝脏的治疗保护作用。方法 88例肝门阻断肝脏手术的病人随机分为黄芪注射液治疗组(Ⅰ组)和非黄芪注射液治疗组(Ⅱ组),术前和术后3d、7d分别检测直接胆红素(DBil)、碱性磷酸酶(ALP)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、γ谷氨酰转移酶(GGT)、白蛋白(Alb),两组资料进行对比分析。结果与Ⅱ组比较,Ⅰ组术后3d、7dAST、ALT明显恢复,差异有统计学意义。结论黄芪注射液对肝门阻断后的肝脏缺血缺氧及再灌注损伤有一定的保护作用。

Objective To evaluate the protective effect of astragalus membranaceus on hepatic injury after hepatic portal vascular occlusion. Methods Eighty-eight patients that underwent liver operation with hepatic portal vascular occlusion were treated. The patients were randomized into astragalus membranaceus-treated group（group Ⅰ ） and control group （group Ⅱ ）. The DBil, ALP, AST, ALT,GGT and Alb were determined before and 3rd, 7th day after the operation, and compared between group Ⅰ and group Ⅱ. Results In the group Ⅰ , the levels of AST and ALT on the postoperative day 3 and 7 were decreased as with the Ⅱ group. There were significant differences between the two groups. Conclusion Astragalus membranaceus has protective effects on hepatic ischemia-reperfusion injury after hepatic portal vascular occlusion.