摘要
目的:分析乳腺神经内分泌癌的病理形态特征,阐明其诊断要点。方法:对确诊为乳腺神经内分泌癌的切除标本18例进行光镜观察和神经元特异性烯醇化酶(NSE)及嗜铬素A(CgA)免疫组织化学染色、8例进行电镜观察,并复习其临床资料。结果:本组患者均为女性,年龄36~77岁,平均53岁,肿瘤大小12~55cm,平均27cm。18例乳腺神经内分泌癌中,典型类癌5例,不典型类癌8例,未分化型小细胞癌5例;电镜下8例癌细胞胞浆内均找到神经内分泌颗粒(NEG);50%以上癌细胞免疫组织化学染色显示NSE及CgA均为阳性反应。结论:乳腺的神经内分泌癌作为乳腺癌的一种罕见类型,我们认为应按照其分化程度及组织结构分为类癌、不典型类癌及未分化型小细胞癌。
Purpose To analyse the pathomorphology of neuroendocrine carcinoma of the breast and to clarify the main points of diagnosis. Methods The pathologic features of 18 cases were observed, all of them immunochemically stained with NSE, chromogranin A, eight of them observed under electron microscope and reviewed their clinical data in all. Results All of the patients were female, aged 36 to 77 years(mean age 53 years). The tumor diameter varied from 1 2 cm to 5 5 cm (mean 2 7 cm). In 18 cases of neuroendocrine carcinoma of the breast, 5 were carcinoid, 8 atypical carcinoid and 5 undifferentiated small cell carcinoma. The results of Immunohistochemistry indicated that NSE and chromogranin A on more than half of the tumor cells were positive. There were neuroendocrine particles in the carcinoma cell of 8 cases observed under electron microscopy. Conclusion As a rare type of the breast carcinoma, neuroendocrine carcinoma of the breast should be classified into carcinoid, atypical carcinoid and undifferentiated small cell carcinoma according to the differentiated grades and histological features of the tumor.
出处
《临床与实验病理学杂志》
CAS
CSCD
1999年第2期104-106,I017,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
免疫组织化学
乳腺癌
神经内分泌癌
breast neoplasms
carcinoma, neuroendocrine
immunohistochemistry
electric microscopy