摘要
目的:探讨前列腺特殊类型癌(PPTC)病理变化、免疫组化表达特点。方法:采用HE及免疫组化方法观察27例PPTC形态学特征。结果:(1)移行细胞癌及鳞癌具有典型的形态,癌细胞无PSA及35βH11表达,cerbB2显阳性。从形态分析,这两种癌可能同源于移行上皮或化生上皮:(2)粘液腺癌、黄色瘤样癌、导管癌、髓样癌、宫内膜样癌、乳头状癌及印戒细胞癌均显PSA及35βH11阳性,提示这几种癌可能来源于分泌上皮;(3)类癌对PSA、35βH11、NSE及CgA均显阳性,符合内分泌细胞来源;(4)小细胞癌无PSA、NSE及CgA表达,对cerbB2及35βH11显阳性,是否来源于前列腺内分泌细胞、储备细胞或基细胞有待证实;(5)27例癌区均无34βE12表达,提示PPTC中基细胞缺失。结论:PPTC少见,组织类型多,形态各异及不同的免疫组化表达,有时诊断较困难,应注意鉴别。
Purpose To study pathomorphological changes, expression of immunohistochemical marks of the prostatic particular types carcinoma (PPTC). Methods Twenty seven cases of PPTC were studied with routin HE and immunohistochemistry technique. Results (1) There were typical morphological pattern in transitional and squamous cell carcinoma, cancer cells did not express PSA and 35βH 11 , but were positive for c erbB 2 protein. These cancer cells might histogenetically be related to the transitional or metaplastic epithelium of prostate according to morphological analysis; (2) Mucinous adenocarcinoma, Xanthomatous carcinoma (foamy gland carciomma), ductal carcinoma, medullary carcinoma, endometrioid carcinoma, papillary carcinoma and signet ring cell carcinoma were positive for PSA and 35βH 11 , these carcinomas might histogenetically be related to prostatic secretory epithelium; (3) Prostatic carcinoid showed positive to PSA, 35βH 11 , NSE and CgA, corresponded with endocrine cell originator; (4) Small cell carcinoma were negative for PSA, 35βH 11 , NSE and CgA, whether or not it originates from endocrine cells, storage cells or basal cell of prostate had yet to be proved; (5) 34βE 12 marking was negative in cancerous areas of 27 cases, and the basal cells were absent in PPTC. Conclusion PPTC are not frequently seen, there are different pathohistohistological types, morphological changes and immunohistochemical reaction, diagnosis is more difficult at times, differential diagnosis is necessary.
出处
《临床与实验病理学杂志》
CAS
CSCD
1999年第2期115-118,I020,共5页
Chinese Journal of Clinical and Experimental Pathology
关键词
前列腺肿瘤
免疫组织化学
病理学
prostatic neoplasms
immunohistochemistry
histogenesis
pathology, clinical