血清学改变与先兆流产的研究

The Research Between Maternal Serum Markers and Threatened Abortion

先兆流产患者有许多可用于评价妊娠结局的母体血清标记物。近年先兆流产患者血清标记物的研究成为重点,如人绒毛膜促性腺激素、孕激素、雌激素、CA125、抑制素A、激活素A、妊娠相关血浆蛋白A和细胞因子等。对先兆流产患者血清学改变行连续测定可指导治疗、评价疗效及预测不良妊娠结局;可避免盲目保胎造成稽留流产;同时也可避免医源性的资源浪费。先兆流产相关血清学改变的连续测定在其诊断及治疗中有重要临床意义。

There are many maternal serum markers investigated in attempts to predict the outcome of pregnancy.The research of maternal serum markers emphasizes on threatened abortion in recent years,such as human chorionic gonadotrophin（hCG）,progestogen,estrogen,CA125,inhibin A,activin A,pregnancy-associated plasma protein-A,cytokine,and so on.Those maternal serum markers could be useful in guiding treatment and evaluating the effectiveness of therapy and predicting adverse pregnancy outcome in women of threatened miscarriage.It can avoid blind tocolyis and resulting in missed abortion.Meanwhile,it also can avoid the waste of medical resource.Thus there is very great clinic significance in diagnosis and therapy for threatened abortion.