术前化疗对胰腺癌细胞凋亡和组织结构的影响

Diagnosis and treatment of gastric carcinoid tumors

目的探讨术前选择性动脉化疗对胰腺癌细胞生长的影响，为临床制定合理的胰腺癌化疗方案提供理论依据。方法运用ＤＮＡ末端标记法对３０例胰腺癌患者术前化疗和未化疗的术后病理切片进行肿瘤细胞凋亡的检测，同时对比观察它们ＨＥ染色的组织结构变化。结果（１）术前化疗组肿瘤细胞凋亡发生率比未化疗组明显增高，两组细胞凋亡数量分别为（４４８７±２７７８）和（３６±３７６）个／高倍视野（Ｐ＜００１）。（２）肿瘤细胞凋亡发生率与组织分型相关，高分化腺癌肿瘤细胞凋亡发生率比中、低分化腺癌明显增高（Ｐ＜００５、Ｐ＜００１）。（３）术前化疗组炎症反应和血管内膜增厚程度明显高于未化疗组（Ｐ＜００５、Ｐ＜００１）。结论术前选择性动脉化疗对胰腺癌细胞的生长有明显抑制作用，并且主要是通过诱导胰腺癌细胞凋亡这一途径实现的。

Objective To investigate the method for surgical diagnosis and treatment of gastric carcinoid tumors. Methods Clinicopathologic features of 9 patients with gastric carcinoid tumors were analyzed retrospectively. The patients were confirmed by biopsy at endoscopy or surgery. Results Eight of the 9 patients underwent elective operation, 6 showed gastric carcinoid tumors before operation found by biopsy at endoscopy. Five tumors were malignant and 4 benign. Two patients showed malignant carcinoid syndrome, but 5 HT and 5 HIAA were normal. Conclusions Benign or malignant gastric carcinoid tumor depends upon tumor size, local lymph node invasion and distant metastases. The prognostic factor is based on benign or malignant tumors. Operation may be the first choice for such patients.