摘要
目的:探讨肌阵挛失神发作的临床症状学、神经电生理学特点及治疗效果。方法:报告1例肌阵挛失神发作的临床表现、脑电图、肌电图特点及治疗效果,并结合文献进行回顾性分析。结果:肌阵挛失神发作临床表现为失神伴双侧节律性肌阵挛,常伴发肢体的强直,脑电图表现为双侧、广泛、节律性3Hz的棘慢复合波,肌电图则表现为与发作期放电频率一致的肌电暴发。此类患者对药物治疗反应较差,伴有强直发作的患者可行胼胝体切开术,该手术可有效减少强直发作导致的跌倒。结论:肌阵挛失神发作病程多样,大部分患者药物治疗反应差,伴有强直发作的患者可以考虑手术治疗。
Objective:To investigate the clinical and electrophysiological characteristics of myoclonic absence(MA) and treatment effectiveness. Methods: The characterastics of clinical manifestation, EEG, EMG and treatment effectiveness were analysed retrospectively. Results: MA is a specific type of seizures, and clinically characterized by the accompanion of diffuse rhythmical myoclonias, often associated with a progressive tonic contraction. The ietal EEG showed paroxysm of generalized spike and slow waves at 3 Hz, and in the polygraphic recording rhythmic 3 Hz myoclonus was observed with a strict correspondence between EEG spike and myoclonus. The response to drug treatment was generally weak,and the patiants with tonic seizures could prevent from falling down after corpus callosotomy. Conclusion: The prognosis of MA remains variable. From most of patients, seizures are resistant to drug treatment. Surgical treatment may be effective in patients with tonic seizures.
出处
《癫痫与神经电生理学杂志》
2010年第6期328-332,共5页
Journal of Epileptology and Electroneurophysiology(China)
关键词
癫痫
肌阵挛
失神
强直
胼胝体切开术
Epilepsy
Myoclonia
Absence
Tonic
Corpus callosotomy