瓜环[n](n=6～8)与盐酸丁咯地尔的相互作用

Interaction of Cucurbit[n]uril(n=6—8) with Buflomedil

利用1HNMR技术、电喷雾质谱、红外光谱及紫外吸收光谱等手段研究了瓜环[n](n=6～8)与盐酸丁咯地尔的相互作用.实验结果表明,盐酸丁咯地尔与3种瓜环具有不同的相互作用,主-客体配合物的作用模式随着瓜环大小的不同而各不相同.其中,瓜环[6]与盐酸丁咯地尔的相互作用非常弱,而瓜环[7]和瓜环[8]则都将盐酸丁咯地尔分子中的吡咯环及其相邻的2个碳全部包结进去,形成了包结比为1:1的对称包结配合物.通过紫外吸收光谱法计算得到瓜环[7]和瓜环[8]与盐酸丁咯地尔分子的包结常数在102～103L/mol范围内,说明瓜环对盐酸丁咯地尔具有潜在的药物缓释作用.

The host-guest chemistry of the systems containing buflomedil（denoted as DLDE） and cucurbit·[n]uril（denoted as CB[n],n=6—8） was investigated by means of 1H NMR,ESI-MS,IR and UV-Vis spectra.The experiment results reveal that the size of the cavity of CB[n] played an important role in the interaction between the host and the guest.Buflomedil could form a stable 1：1（molar ratio） inclusion complex with CB[7] and CB[8],whereas the intereaction of buflomedil with CB[6] was very weak.The inclusion constants of buflomedil with CB[7] and CB[8] were 1.43×103 and 3.76×102 L/mol,respectively.The binding constant which located between 102—103 L/mol indicates that CB[7] and CB[8] can be used as a potential slow-released agent.