细胞自噬与机体免疫机制及抗微生物感染的关系

Autophagy was association with immunity and anti-microbial infection of host cells

细胞自噬作为细胞的一种生理机制,一方面为细胞提供再生资源,一方面也可以作为防御机制抵抗微生物的感染和寄生。本文对它与先天性免疫、适应性免疫的关系做了综述,并探讨了自噬与微生物感染的关系。本文为我们理解细胞自噬在机体抗感染机制中的作用提供了帮助,也为我们研究感染性疾病治疗药物开启新的视野。

Autophagy is physiological mechanism of cells.It provides renewable resources for cells,and functions as the defense mechanism of host cells resisting microbial infection or parasitic.This review described the relationship between autophagy and innate and adaptive immunity,as well as the interaction between autophagy and microbial infection.This would help us understand the roles of autophagy in host＇s anti-infection mechanism,and bring a new view of drug development for controlling infectious diseases in the future.