二氢叶酸还原酶与肿瘤耐药

Dihydrofolate reductase and tumor resistance

二氢叶酸还原酶是核酸代谢中的关键酶之一,是肿瘤化疗药物的主要靶酶。随着人们对其在基因水平研究的逐渐深入,发现氨甲蝶呤的靶酶二氢叶酸还原酶是引起耐药的主要原因。本文就二氢叶酸还原酶结构、功能及其与肿瘤耐药关系作一综述,并探讨其在临床的应用前景和意义。

Dihydrofolate reductase（DHFR）,a key enzyme in nucleic acid metabolism,is one of the important target enzymes of tumor resistance.With the research of genomics of DHFR,it has been found that dihydrofolate reductase,the target enzyme of methotrexate,is the main reason for drug resistance.This paper summarized the structure,function of DHFR and its relationship with tumor resistance and described its application and significance in clinic.