房室结纤维和脂肪增多与房室结动脉狭窄的关系

Relationship between the Increase of Fibrous and Fatty in Atrioventricular Node and Narrowing of the Atrioventricular Node Artery

目的探讨房室结纤维、脂肪含量与房室结动脉狭窄之间的关系,分析房室结内病理性纤维化和病理性脂肪浸润的原因。方法选取119例心源性猝死案例,用Image-pro plus图像分析软件检测组织切片,计算房室结面积,房室结动脉内径、房室结动脉管腔面积(lumen area,LA)、外周横截面积(perimeterarea,PA),纤维组织面积和脂肪组织面积。将所有案例分为动脉狭窄组和正常对照组组,观察房室结动脉PA/LA值及房室结纤维及脂肪含量的改变。结果狭窄组房室结动脉PA/LA值在21～40岁最大,40岁以下两组房室结脂肪含量和总间质含量差异有统计学意义。结论房室结动脉狭窄与房室结间质含量增多有一定关系。

Objective To explore relationship between increase of fibrous and fatty in atrioventricular node（AVN） and narrowing of the AVN artery.To analyze the cause of pathological fibrosis and fatty infiltration in AVN.Methods One hundred and nineteen cases of sudden cardiac death determined by autopsy were selected and the histological sections were examined with Image-pro plus software to calculate the AVN area,AVN artery inside-diameter,AVN artery lumen area（LA）,AVN artery perimeter area（PA）,fibrous area and fatty area.All cases were divided into two groups： narrowing of artery group and normal control group.The changes of the PA/LA value and the fibrous and fatty contents were evaluated.Results The PA/LA value is the highest in 21-40 age group.The difference of the fatty contents and total interstitial tissue was statistical significance in the two groups under 40 years of age.Conclusion There is some relationship between the narrowing of the AVN artery and the increase of interstitial contents in AVN.