Secondary metabolites from marine derived fungus Penicillium terrestre

真菌Penicillium terrestre的化学成分研究(英文)

Chemical examination of an unidentified sponge associated marine fungus Penicillium terrestre resulted in the isolation of eight compounds. Their structures are identified as cyclo （glycyl-D-proline） （1）, cyclo （L-prolyl-L-alanine） （2）, cyclo （L-prolyl- D-alanine） （3）, cyclo （L-leucyl-trans-4-hydroxy-L-proline） （4）, cyclo （L-leucyl-cis-4-hydroxy-D-proline） （5）, cyclo （L-trans-（4- hydroxyprolinyl）-L-phenylalanine） （6）, hexylitaconic acid （7）, and hexylitaconic methylate （8）, based on spectroscopic analysis （1D, 2D NMR）. Compounds 7, 8 were obtained from the genus Penicillium for the first time, while compounds 1-6 were isolated from the fungus Penicillium terrestre for the first time.

对分离自南海海绵的真菌Penicillium terrestre中的化学成分进行研究。采用多种色谱手段进行分离纯化,得到单体化合物,通过理化性质及波谱方法(1D,2D NMR)确定化合物结构。分离得到的8个化合物分别为cyclo(glycyl-D-proline)(1),cyclo(L-prolyl-L-alanine)(2),cyclo(L-prolyl-D-alanine)(3),cyclo(L-leucyl-trans-4-hydroxy-L-proline)(4),cyclo(L-leucyl-cis-4-hydroxy-D-proline)(5),cyclo(L-trans-(4-hydroxyprolinyl)-L-phenylalanine)(6),hexylitaconic acid(7),hexylitaconicmethylate(8)。化合物7,8为首次从该属中分得,其余化合物为首次从该种中分得。