甘肃人群NQO1基因多态性与急性髓系白血病易感性的关系

Relationship between NQO1 gene polymorphisms and susceptibility of acute myeloid leukemia in Gansu population

目的:研究醌氧化还原酶(NQO1)基因多态性和急性髓系白血病易感性的关系。方法:用1:1配对病例-对照方法,PCR-LDR方法,对78例急性髓系白血病患者(AML)和100例对照人群进行NQO1基因突变分析。结果:AML病例组NQO1基因T等位基因频率(43%)和TC/TT基因型频率(63%)均高于对照组(28%和43%)。携带TC/TT基因型的个体发生AML的相对风险度为其野生型(CC)的1.67倍(95%CI=1.212～2.727)。结论:NQO1基因多态性与AML遗传易感性相关,等位基因C对AML易感性有保护作用。

Objective：To explore the relationship between quinone oxidoreductase 1（NQO1）gene polymorphisms and the susceptibility of the acute myeloid leukemia in Gansu population.Method：The C609 Tpolymorphism of NQO1 gene was investigated by polymerase chain reaction-ligase detection reaction（PCR-LDR）in 100 normal people（control group）and 78 people with acute myeloid leukemia（AML group）.Result：The T allele genotype and TC/TT genotype of NQO1gene occurred more frequently in AML group（43% and 63%）than those in control group（28% and 43%）（P〈0.05）.The people with TC/TT genetype had increased 1.67-fold AML risk,compared with the individual with CC genotype（95% CI=1.212～2.727）.Conclusion：NQO1 gene polymorphism was associated with the susceptibility of acute myeloid leukemia in Gansu population.The risk of AML was increased in the persons carrying allele T.