摘要
炎症性肠病(inflammatory bowel disease,IBD)是一种病因未明的慢性非特异性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD).DPP-4抑制剂是近年来发现的一种治疗糖尿病的新靶点药物,而最近有研究表明,DPP-4抑制剂对动物肠炎模型有一定的治疗作用,这可能为炎症性肠炎的治疗开辟新的治疗途径.
Inflammatory bowel disease(IBD) is a chronic,debilitating disease associated with severe damage to the intestinal mucosa whose etiology is still unknown.The two most common forms of IBD are ulcerative colitis(UC) and Crohn's disease(CD) .DPP-4 inhibitors are a new class of agents developed for treatment of diabetes. However,recent studies have indicated that DPP-4 inhibitors have therapeutic effects against IBD in animal models.This may provide a new avenue to cure IBD.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第30期3215-3219,共5页
World Chinese Journal of Digestology