DPP-4抑制剂与炎症性肠病

DPP-4 inhibitors and inflammatory bowel disease

炎症性肠病(inflammatory bowel disease,IBD)是一种病因未明的慢性非特异性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD).DPP-4抑制剂是近年来发现的一种治疗糖尿病的新靶点药物,而最近有研究表明,DPP-4抑制剂对动物肠炎模型有一定的治疗作用,这可能为炎症性肠炎的治疗开辟新的治疗途径.

Inflammatory bowel disease（IBD） is a chronic,debilitating disease associated with severe damage to the intestinal mucosa whose etiology is still unknown.The two most common forms of IBD are ulcerative colitis（UC） and Crohn＇s disease（CD） .DPP-4 inhibitors are a new class of agents developed for treatment of diabetes. However,recent studies have indicated that DPP-4 inhibitors have therapeutic effects against IBD in animal models.This may provide a new avenue to cure IBD.