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MTSS1在大肠良恶性组织中的表达及其意义 被引量：9

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摘要 目的探讨MTSS1(metastasis suppressor1)在大肠癌组织、癌前病变(腺瘤性息肉)、正常组织中的表达及其意义。方法采用免疫组织化学检测MTSS1在大肠癌组织、癌前病变(腺瘤性息肉)、正常组织中的表达,并用单因素分析法研究其与临床病理因素的关系。结果 MTSS1表达阳性率大肠癌组织比正常组织高,差异有统计学意义(P<0.05);大肠癌组织比癌前病变(腺瘤性息肉)高,差异有统计学意义(P<0.05);转移性比局限性大肠癌高,差异有统计学意义(P<0.05)。MTSS1在大肠癌中的表达与患者的性别、年龄、肿瘤大小、TNM分期无关(P>0.05)。正常组织与癌前病变(腺瘤性息肉)的MTSS1表达阳性率差异无统计学意义(P>0.05)。结论 MTSS1异常表达可能与大肠癌发生侵袭转移有关,可为临床治疗提供新的靶点。
作者 王鼎 徐美荣 朱建伟
机构地区 南通大学附属医院普外科
出处 《中华临床医师杂志（电子版）》 CAS 2010年第12期122-124,共3页 Chinese Journal of Clinicians(Electronic Edition)
基金 国家自然科学基金(30771126 30772106) 教育部回国留学人员基金(2008-890) 江苏省自然科学基金(BK2006058)
关键词 肠肿瘤 免疫组织化学 肿瘤侵润 肿瘤转移 MTSS1
分类号 R735.34 [医药卫生—肿瘤]
  • 相关文献

参考文献15

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二级参考文献7

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共引文献12

同被引文献98

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引证文献9

二级引证文献14

中华临床医师杂志（电子版）
2010年 第12期

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