保肝降脂饮对非酒精性脂肪性肝炎大鼠血清瘦素含量的影响

Effects of Baoganjiangzhiyin on content of leptin in non-alcholic steatohepatitis rats

目的:观察保肝降脂饮对大鼠血清中瘦素含量的影响,从而探讨保肝降脂饮治疗该病的药学机制。方法:采用高脂饮食诱导建立大鼠非酒精性脂肪性肝炎模型,实验分为模型组(简称M组),保肝降脂饮大、中、小剂量组(分别简称D、Z、X组),东宝肝泰对照组(简称B组)和正常对照组(简称A组)共6组。观察各组大鼠血清中瘦素水平。结果:M组大鼠血清中瘦素含量明显高于用药各组和A组(P<0.01),而各用药组之间比较,差异均无显著性意义(P>0.05)。结论:保肝降脂饮可以显著降低大鼠血清中瘦素含量,减少肝细胞内脂肪酸的含量,减轻肝脏脂肪变性,达到治疗非酒精性脂肪性肝炎的目的。

Objective：To investigate the curing effect of Baoganjiangzhlyin on steatoheptatis.Methods：The rat model of steatoheptatis was induced by feeding rats with high fat diet.Sixty ale SD rats were divided into six groups randomly：three model groups of six groups were espectively fed with high,median and law doses of Baoganjiangzhiyin,and in another three groups and one group of ratt one model group was fed with Dongbaogantai,one model steatohepatitis group and one group of rats with nomal liver function were used as contrast groups,respectively.Baoganjiongzhiyin and Dongbaogantai were give to the model rats with fatty liver.And the changes of the contents of Leptin in sera were observed and compared with those in the normal control group.Results：Model of rats steatohepatitis had a significantly higher level of Leptin in their sera than other groups（P0.01）,But treatment groups include Dongbaogantai group had a same level of Lepatin in their sera（P0.05）.Conclusion：Baoganjiangzhiyin can achieve the purpose of treatment of fatty liver by reduce serum lveels of Leptin,reduce fatty acids in liver cells,reduce hepatic steatosis.