基于同一天然手性源(4R)-羟基脯氨酸的(2S,4S)/(2S,4R)-4-氟谷氨酸的立体专一性合成

Stereospecific Synthesis of (2S,4S)/(2S,4R)-4-Fluoroglutamic Acids Base on Natural Chiral Source (4R)-Hydroxyproline

基于同一天然手性源(4R)-羟基脯氨酸,通过Mitsunobo反应、全氟丁基磺酰氟作用下的氟化反应以及NaIO4/RuO2作用下的氧化反应,立体专一性地合成了(2S,4S)/(2S,4R)-4-氟谷氨酸.

Stereospecific synthesis of （2S,4S）/（2S,4R）-4-fluoroglutamic acids base on natural chiral source （4R）-hydroxyproline was studied by using of Mitsunobo reaction, fluorination with perfluoro-1-butanesul- fonyl fluoride and NaIO4/RuO2 oxidation.