前列地尔治疗急性脑干梗死的疗效评价及其对血清IL-6和TNF-α及S100B的影响

Effect of Lipo-PGE1 in Treating Acute Brainstem Infarction and Its Impact on Serum IL-6,TNF-α and S100B

目的探讨前列地尔治疗急性脑干梗死的疗效及其对血清白介素6(IL-6)、肿瘤坏死因子α(TNF-α)和S100B水平的影响。方法将60例急性脑干梗死患者随机分为治疗组和对照组,两组均给予常规治疗,治疗组另加用前列地尔治疗。分别于入院第1天(治疗前)、第3天、第14天检测两组患者的血清IL-6、TNF-α及S100B水平并进行比较,并根据美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数(BI)评分判断前列地尔治疗急性脑干梗死的疗效。结果入院第1天(治疗前),两组患者的血清IL-6、TNF-α及S100B水平间差异均无统计学意义(P>0.05)。入院第3天,治疗组血清IL-6、TNF-α及S100B水平降低,而对照组IL-6、TNF-α及S100B水平增高,两组比较差异有统计学意义(P<0.05)。入院第14天,治疗组血清IL-6、TNF-α及S100B水平较第3天继续下降,与对照组比较,降低更明显(P<0.05)。入院第1天,两组患者的NIHSS评分、BI评分间差异均无统计学意义(P>0.05);入院第14天治疗组的NIHSS评分较治疗前显著降低,第28天治疗组的BI评分较治疗前显著提高,与对照组比较,差异均有统计学意义(P<0.05)。结论急性脑干梗死患者应用前列地尔治疗可以显著降低IL-6、TNF-α及S100B的表达,改善其预后。

Objective To investigate the effect of Lipo-PGE1 in treating acute brainstem infarction and its impact on serum IL-6,TNF-α and S100B.Methods 60 patients with acute brainstem infarction were randomly divided into treatment group and control group,and the levels of IL-6,TNF-α and S100B were examined and compared on admission（before treatment）,3 days and 14 days after hospitalization.NIHSS score and Barthel Index Score（BI）were applied to evaluate the effect of Lipo-PGE1 in treating acute brainstem infarction.Results There were no statistical differences in the levels of IL-6,TNF-α and S100B between the two groups on admission（before treatment）（P〈0.05）.The levels of IL-6,TNF-α and S100B in treatment group reduced while they increased in control group three days after hospitalization,and the difference was significant（P〈0.05）.The levels of IL-6,TNF-α and S100B in treatment group reduced further 14 days after hospitalization,and the difference was more significant compared with control group（P〈0.05）.The scores of NIHSS and BI were not significantly different on admission（P〈0.05）.The NIHSS score reduced significantly 14 days after hospitalization,and BI score increased significantly 28 days after hospitalization,the difference was significant compared with that of the control group（P〈0.05）.Conclusion Application of Lipo-PGE1 in patients with acute brainstem infarction can significantly reduce the expression of IL-6,TNF-α and S100B and can improve prognosis.