阻塞性睡眠呼吸暂停低通气综合征患者血清脑红蛋白水平的变化与早期脑损伤的相关性

Correlation between changes of serum neuroglobin and early brain injury in inpatients with obstructive sleep apnea-hypopnea syndrome

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清中脑红蛋白水平的变化与早期脑损伤的相关性。方法采用酶联免疫吸附法检测经多导睡眠监测仪监测确诊的40例OSAHS患者和16例健康体检者血清脑红蛋白水平。结果轻、中、重度OSAHS组脑红蛋白水平较对照组明显增高(P<0.05或P<0.01),OSAHS患者3组间脑红蛋白水平比较,有显著性差异(P<0.01),与呼吸暂停低通气指数呈正相关(r=0.948,P<0.01),与最低血氧饱和度呈负相关(r=-0.800,P<0.01),与血氧饱和度低于90%的时间占总睡眠时间的百分比无明显相关性(r=-0.005,P>0.05)。结论 OSAHS患者的血清脑红蛋白水平升高,可能与早期脑损伤有一定的相关性。

Objective To explore the correlation between the changes of serum neuroglobin and the early brain injury in inpatients with obstructive sleep apnea-hypopnea syndrome（OSAHS）. Methods 40 patients with OSAHS and 16 normal controls were evaluated by full-night polysomnography. Serum levels of neuroglobin were detected by enzyme-linked immunosorbent assay method. Results Serum levels of neuroglobin of the mild,moderate and severe OSAHS group were all obviously higher than those of the control group（P0.05 or P0.01）,and serum neuroglobin levels among the three OSAHS groups had a significant difference（P0.01）.The concentrations of serum neuroglobin in patients with OSAHS were positively correlated with apnea-hypopnea index（r=0.948,P0.01）,while they were negatively correlated with lowest oxygen saturation （r=-0.800,P0.01）.There was not a significant relationship（r=-0.005,P0.05） between the degree of neuroglobin and cumulative percentage of sleep time with oxygen saturation level below 90%.Conclusion The serum neuroglobin in inpatients with OSAHS may have a signifi- cant correlation with early brain injury.It can be acted as a predictor for it.