L-脯氨酸催化的醛的不对称α-硫代反应

Asymmetric α-Sulfenylation of Aldehydes Catalyzed by L-Proline

目的:对L-脯氨酸催化醛的不对称α-硫代反应进行研究。方法:以L-脯氨酸为催化剂,将正丙醛和正丁醛分别与7种硫代试剂在-40℃下反应6小时。结果:合成了14个α-硫代醛类化合物,结构经1H-NMR确证。结论:L-脯氨酸可催化醛的α-硫代反应,且产率较高,具有一定实用价值。

Objective：To study the chiral α-sulfenylation of aldehydes catalyzed by L-proline.Methods：The L-proline was used to catalyze the sulfenylation,in which two kinds of aldehydes and seven kinds of sulfenylation agents were tested,respectively.The reactions sustained for 6 hours at-40 ℃.Results：14 α-sulfenylated aldehydes were synthesized,and their structures were confirmed by 1H-NMR.Conclusion：L-Proline can catalyze α-sulfenylation of aldehydes,and its productivity is high.It is feasible and has a practical value of application.