胆囊结石形成的胆囊动力学研究进展

Research development of kinetic mechanism of gallstone formation

研究表明胆囊收缩功能障碍在胆囊结石的形成中起着重要作用,该文就以下6个方面有关胆囊动力学的研究情况作一综述:①胆囊运动功能的神经调节和体液调节;②胆囊动力学分级及诊断方法;③胆囊结石患者的胆囊收缩素(CCK)水平;④胆囊结石与胆囊排空障碍;⑤胆囊排空障碍的分子生物学研究;⑥胆汁胆固醇与胆囊收缩素受体(CCK-R)基因表达。

Some studies indicate that the decreased gallbladder contractility may be the key factor responsible for gallstone formation.This article discusses the kinetic mechanism of gallstone formation from the following aspects： ①Nervous and humoral regulation of gallbladder emptying function;②Classification and diagnosis of gallbladder function;③Changes of plasma cholecystokinin（CCK） levels in patients with gallstone;④Correlation between gallstone and gallbladder dysmotility;⑤The molecular mechanism of gallbladder dysmotility;⑥Correlation between gene expression of cholecystokinin receptor（CCK-R） and cholesterol in bile.