高压氧治疗Bell麻痹的系统评价

Hyperbaric oxygen for Bell palsy: a systematic review

目的了解是否有足够的证据表明高压氧治疗Bell麻痹有效。方法电子检索PubMed、Ovid、TheCochrane central Register of Controlled Trails、EMbase、Science Citation Index Expanded、HighWire Press、中国生物医学文献数据库(CBMDisc)、中国知网(CNKI)、维普数据库(VIP),文献检索起止时间均为从建库到2010年2月,同时检索纳入文献的参考文献,纳入高压氧治疗Bell麻痹的的随机对照试验,进行质量评价及资料提取。统计学分析采用RevMan5.0.22.0软件。结果共检索到随机对照试验10个,病例823例。所有研究认为高压氧可以提高面神经麻痹的治愈率和有效率。结论现有证据提示高压氧治疗面神经麻痹很有前途,但是严格设计的RCT证据数量太少,质量有待改进,结果说服力不强,还需要更多高质量的RCT证实其疗效,以便在国内外推广。

【Objective】 To explore whether there is enough clinical evidence to confirm that hyperbaric oxygen（HBO） does more good than harm in patients with Bell palsy.【Methods】 Trials are located through electronic searches of the PubMed,Ovid,the Cochrane Central Register of Controlled Trails,EMbase,Science Citation Index Expanded,the China Biological Medicine Database） CBM-disc,（the Chinese National Knowledge Infrastructure） CNKI from the date of establishment of the databases to February 2010.Bibliographies of the retrieved articles were also checked.【Results】 A total of 10 trials involving 823 patients were included.All studies reported positive results regarding the effects.However,the quality of the included studies was generally poor.The main problem was that most trials reported them as a RCT without evidence.However,at present,we could not draw definite conclusion that the treatment does more good than harm.【Conclusions】 HBO in the treatment of Bell palsy is promising based on present harm compared with other treatment because of the poor qualities of included studies.Therefore,more high quality RCTs are required.