不同剂量ACEI对收缩性心力衰竭患者血浆BNP水平的影响

Effect of different doses of ACE inhibitor on plasma B-type natriuretic peptide levels in patient with systolic heart failure

目的观察不同剂量培哚普利对收缩性心力衰竭患者血浆B型利钠肽(BNP)水平及6min步行试验结果的影响。方法 28例在该院住院治疗的收缩性心力衰竭患者治疗前及治疗后3个月检测血浆BNP及6min步行试验,前3个月给予培哚普利4mg/d,后3个月给予培哚普利8mg/d;探讨ACEI对血浆BNP水平及6min步行试验结果有无影响。结果服药后血浆BNP水平较服药前下降明显(P<0.01),服药后6min步行试验距离较服药前增加明显(P<0.01),服培哚普利8mg3个月者血浆BNP水平较服培哚普利4mg3个月者下降明显(P<0.01),服培哚普利8mg3个月者6min步行试验距离较服培多普利4mg3个月者明显增加(P<0.01)。结论服8mg比服4mg培哚普利能更好地降低心衰患者血浆BNP水平,改善患者症状。

【Objective】 To investigate the effect of different doses of perindopril on plasma B-type natriuretic peptide levels and the distance walked in the 6-minute walk test.【Methods】 A total of 28 patients with systolic heart failure were assessed at baseline and every three months,with doses of 4 mg of perindopril in the first 3 months and 8 mg in the following 3 months.【Results】 In group both at 8 mg and at 4 mg,BNP levels were lower and the distance walked in the 6-minute walk test was longer compared to baseline （P 0.05）.In group taking 8 mg of perindopril,BNP levels were lower and the distance walked in the 6-minute walk test was longer compared to group with 4 mg （P 0.05）.【Conclusion】 High dose of perindopril is better in reducing plasma B-type natriuretic peptide levels and improving symptoms in patients with systolic heart failure.