消化系统肿瘤FDG PET/CT显像标准摄取值与分子生物学的相关性

The association of FDG-PET/CT SUV with molecular biology in digestive canal cancer

目的探讨消化系统肿瘤PET/CT显像FDG标准摄取值(SUV)与其分子生物学行为的相关性。方法回顾性分析资料完整的24例消化系统肿瘤患者PET/CT、手术和病理资料,分析患者PET/CT显像FDG摄取指数SUV值与癌肿浸润深度、转移状况之间的相关性以及与肿瘤增殖因子Ki-67、癌基因p53、癌基因C-erbB-2表达的相关性。结果 24例消化系统肿瘤患者SUV值最低为2.5,最高为12,平均值6.34±2.54,按SUV值高低将患者病变均分为低代谢和高代谢两组,低代谢组SUV均值4.39±1.31,高代谢组SUV均值8.48±1.38,两组间SUV值均数差异有统计学意义(t=2.418,P<0.05),两组间病变浸润深度差异无统计学意义(χ2=0,P>0.05),两组间病变邻近淋巴结转移发生率无统计学意义(χ2=0.686,P>0.05)。24例患者病变Ki-67值最低为20%,最高为65%,平均值(41±11)%。SUV值与Ki-67值相关性无统计学意义(r=-0.22,P>0.05)。低代谢组和高代谢组Ki-67值分别为(43±13)%和(38±9)%,组间差异无统计学意义(t=0.225,P>0.05)。低代谢组和高代谢组p53阳性表达例数差异无统计学意义(χ2=0.711,P>0.05)。低代谢组和高代谢组C-erbB-2阳性表达例数差异无统计学意义(χ2=0.686,P>0.05)。结论消化系统肿瘤PET/CT显像FDG摄取指数SUV值变异较大,与癌肿浸润深度和邻近淋巴结有无转移之间没有相关性,与肿瘤增殖因子Ki-67、癌基因p53及C-erbB-2表达程度无显著相关性。

Objective To investigate the association of FDG uptake index of digestive canal cancer PET image with molecular biological behaviour.Methods Twenty-four patients with digestive canal cancer with complete PET/CT,surgical operation and pathology data were enrolled.Retrospectivly analyzed the correlation between FDG uptake index（SUV value） and cancer infiltration,and lymph node metastasis and Ki-67,p53,C-erbB-2 expression.Results The FDG uptake index SUV value of 24 subjects,the lowest was 2.5,the highest was 12,the average was 6.34 ± 2.54,were divided equally into hypometabolism group and hypermetabolism group,hypometabolism group average SUV was 4.39 ± 1.31,hypermetabolism group average SUV was 8.48 ± 1.38,the discrepance of SUV average value between two groups had statistical significance（t =2.418,P 〈0.05）,the discrepance of cancer infiltrating depth had no statistical significance（χ2 =0,P 〉 0.05）,the discrepance of incidence of lymphaden metastasis had no statistical significance（χ2 = 0.686,P 〉 0.05） .The Ki-67 value of 24 subjects,the lowest was 20%,the highest was 65%,the average was（41 ± 11） % .The associativity of SUV value and Ki-67 value had no statistical significance（r =-0.22,P 〉 0.05） .The Ki-67 value of hypometabolism and hypermetabolism were（43 ± 13） % and（38 ± 9） % respectively,the discrepance of two groups had no statistical significance（t = 0.225,P 〉 0.05 ） .The discrepance of p53 positive cases of hypometabolism and hypermetabolism had no statistical significance（χ2 =0.711,P 〉0.05） .The discrepance of C-erbB-2 positive cases of hypometabolism and hypermetabolismhad no statistical significance（χ2 = 0.686,P 〉 0.05） .Conclusions The SUV of digestive canal cancer PET image 18F-FDG standard uptake value had comparatively large variation,had no significant associativity with cancer infiltrating depth and neighbourhood lymphaden metastases,had no significant associativity with the expression of tumor multiplication factor Ki-67,oncogene p53 and C-erbB-2.