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Kazal型人类丝氨酸蛋白酶抑制因子研究现状 被引量：4

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摘要 在肿瘤的生长、血管生成以及浸润和转移过程中，除了生长因子与抑癌基因突变、细胞周期改变等上游机制的参与外，蛋白酶扮演了最终共同途径的角色，并且在功能性或病理性组织重建过程中起到重要的作用。大量实验证明，
作者 迟庆 伦永志
机构地区 大连大学医学院辽宁省高校生物物理学重点实验室
出处 《中华临床医师杂志（电子版）》 CAS 2010年第8期117-119,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 蛋白酶抑制因子 丝氨酸 人类 l型 生长因子 浸润和转移 癌基因突变 血管生成
分类号 R730.2 [医药卫生—肿瘤]
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参考文献22

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同被引文献74

  • 1周游,李龄,蒋先惠.软脑膜下多处横切术的手术原理和适应证[J].功能性和立体定向神经外科杂志,1994,7(3):37-38. 被引量：3
  • 2Lopez-Otin C, Overall C M. Protease degradomies: a new challenge for proteomics. Molecular Cell Biology, 2002, 3(7): 509-519.
  • 3Clynen E, Schoofs L, Salzet M. A Review of the most important classes of serine protease inhibitors in insects and leeches. Medicinal Chemistry Reviews, 2005, 2(3): 197-206.
  • 4Zhao Y, Sun W, Zhang P, Chi H, Zhang M J, Song C Q, Ma X, Shang Y, Wang B, Hu Y, Hao Z, Huhmer A F, Meng F, L'Hemault S W, He S M, Dong M Q, Miao L. Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin). Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(5): 1542-1547.
  • 5Park H J, Seong Y M, Choi J Y, Kang S, R-him H. Alzheimers disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi. Neuroscience Letters, 2004, 357(1): 63-67.
  • 6Hook G, Hook V, Kindy M. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. Journal of Alzheimer's Disease, 2011, 26(2): 387-408.
  • 7Kim J T, Song E Y, Chung K S, Kang M A, Kim J W, Kim S J, Yeom Y I, Kim J H, Kim K H, Lee H G. Up-regulation and clinical significance of serine protease kallikrein 6 in colon cancer. Cancer, 2011, 117(12): 2608-2619.
  • 8Krowarsch D, Cierpicki T, Jelen F, Otlewski J. Canonical protein inhibitors of serine proteases. Cellular and Molecular Life Science, 2003, 60(11): 2427-2444.
  • 9Hibbetts K, Hines B, Williams D, An overview of proteinase inhibitors. Journal of Veterinary Internal Medicine, 1999, 13(4): 302-308.
  • 10Magdolen V, de Prada N A, Sperl S, Muehlenweg B, Luther T, Wilhelm O G, Magdolen U, Graeff H, Reuning U, Schmitt M. Natural and synthetic inhibitors of the tumor-associated serine protease urokinase-type plasminogen activator. Advanced in Experimental Medecine and Biology, 2000, 477:331-341.

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中华临床医师杂志（电子版）
2010年 第8期

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